Thiol ligands and complexes for X-ray imaging

Details Thiol ligands and complexes for X-ray imaging Thiol ligands and complexes for X-ray imaging

1995-03-10

1997-04-01

Nazario-Gonzalez, Porfirio

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

424 9365, 436173, 514492, 514503, 534 15, 534 16, 556 57, 556 61, 556 63, 556 64, 556 77, 556 81, 556107, 562556, A61B 5055, C07F 994

Patent

active

056163126

ABSTRACT:
The present invention provides new and structurally diverse compositions comprising compounds of the general formula: ##STR1## Wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, and R.sup.5 are the same or different and are --CO--(CH.sub.2).sub.y --SH, --(CH.sub.2).sub.2 --SH, --SO.sub.2 --(SH.sub.2).sub.t --SH,--SH,--(CH.sub.2).sub.q --COOH, and --(CH.sub.2).sub.v --CONR.sup.6 R.sup.7, provided at least one of R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 is a sulfur containing moiety; n is 0 to about 10; i is 2 to about 5; j is 2 to about 5; y is 1 to about 5; z is 1 to about 6; t is 1 to about 5; q is 1 to about 5; v is 1 to about 5; R.sup.6 is H, alkyl, hydroxyalkyl, polyhydroxyalkyl, arylalkyl or alkoxyalkyl; R.sup.7 is H, alkyl, hydroxyalkyl, polyhydroxyalkyl, arylalkyl or alkoxyalkyl; and R.sup.7 can be polyamine when R.sup.6 is H.
Methods for imaging using compositions of the invention are also provided.

REFERENCES:
patent: 5314680 (1994-05-01), Rajagopalan et al.
patent: 5463030 (1995-10-01), Subramanian et al.
patent: 5466438 (1995-11-01), Unger et al.
patent: 5466439 (1995-11-01), Gibby et al.
patent: 5466878 (1995-11-01), Junino et al.
patent: 5476644 (1995-12-01), Illig et al.

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