Thiol-based NAALADase inhibitors

Details Thiol-based NAALADase inhibitors Thiol-based NAALADase inhibitors

2006-01-31

2006-01-31

Davis, Brian (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C562S429000, C562S431000, C562S432000, C514S562000, C514S570000, C514S571000

Reexamination Certificate

active

06992215

ABSTRACT:
This invention relates to new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neuronal activity, effecting TGF-β activity, inhibiting angiogenesis, and treating glutamate abnormalities, diabetic neuropathy, pain, compulsive disorders, prostate diseases, cancers and glaucoma.

REFERENCES:
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patent: WO 01/92274 (2001-12-01), None
Suh et al., “Zn(II)-Chelating Inhibitors of Carboxypeptidase A”,Bioorganic&Medicinal Chemistry Letters, Mar. 16, 1995, pp. 585-588, vol. 5, No. 6, Elsevier Science Ltd., Amsterdam, NL.
Database CAPLUS on STN. Acc. No. 1986: 553545, Kato, JP 61027957 (abstract), (1986).
EPO Abstract of JP61027957. (1986).

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