Thiol activation of cytotoxic and auxin-herbicidal agents and ro

Details Thiol activation of cytotoxic and auxin-herbicidal agents and ro Thiol activation of cytotoxic and auxin-herbicidal agents and ro

1995-02-28

1997-07-01

Clardy, S. Mark

Plant protecting and regulating compositions

Plant growth regulating compositions

Plural active ingredients

504144, 504145, 504254, 504323, 504324, 47 58, 47DIG3, 435 74, 435 25, 514592, 514706, A01N 4340, A01N 3902, A01N 3904, A01N 3710

Patent

active

056438532

ABSTRACT:
Thiol compounds are employed in conjunction with compounds which modulate self proliferation, both as to plants and mammals. The thiol compounds find effect in enhancing the effectiveness of auxin like compounds, either as herbicides or in enhancing root formation. In addition, thiol compounds act in conjunction with cytotoxic agents in mammals to allow for lower dosages of the cytotoxic agents while retaining the cytotoxic effect against hyperproliferative diseases, such as cancer. The combination finds particular effect against cells dependent upon an isoform of a surface membrane NADH oxidase for proliferation.

REFERENCES:
patent: 4169720 (1979-10-01), Schacht et al.
patent: 4396418 (1983-08-01), Schirmer et al.
Morre et al. "Selective Inhibition of Auxin-Stimulated NADH Oxidase Activity and Elongation Growth of Soybean Hypocotyls by Thiol Reagents", Plant Physiology. 107:1285-1291. Apr. 1995.
Morre et al. "Auxin-Modulated Protein Disulfide-Thiol-Interchange Activity from Soybean Plasma Membranes", Plant Physiology. 109:573-578. Oct. 1995.
Standardi, et al., Effects of Some Antioxidants on in Vitro Rooting of Apple Shoots (1990) HortScience 25(11):1435-1436.
Centre horicole de Lullier, Ecole d'ingenieurs ETX, 1254 Lullier, Switzerland, II.1 Rooting of in Vitro Cuttings (1991) Biotechnology in Agriculture and Forestry, vol. 17, 231-261.
Lane, Regeneration of Apple Plants from Shoot Meristem-Tips (1978) Plant Science Letters, 13 281-285.

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