Organic compounds -- part of the class 532-570 series – Organic compounds – Sulfonic acids or salts thereof
Reexamination Certificate
2005-02-08
2005-02-08
Barts, Samuel (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Sulfonic acids or salts thereof
C562S023000, C562S011000, C514S576000
Reexamination Certificate
active
06852878
ABSTRACT:
Thioketals and thioethers are provided that inhibit the expression of VCAM-1, and which can be used in the treatment of VCAM-1 mediated diseases including inflammatory disorders, cardiovascular diseases, occular diseases, autoimmune diseases, neurological disorders, and cancer. The compounds also can be used to treat hyperlipidemia and/or hypercholesterolemia.
REFERENCES:
patent: 3179701 (1965-04-01), Rocklin
patent: 3485843 (1969-12-01), Wang
patent: 3576883 (1971-04-01), Neuworth
patent: 3704327 (1972-11-01), Neuworth
patent: 3897500 (1975-07-01), Neuworth
patent: 4076841 (1978-02-01), Wagner et al.
patent: 4115590 (1978-09-01), Lerner
patent: 4734527 (1988-03-01), Krauss
patent: 4752616 (1988-06-01), Hall et al.
patent: 4755524 (1988-07-01), Mueller et al.
patent: 4954514 (1990-09-01), Kita et al.
patent: 5206247 (1993-04-01), Regnier et al.
patent: 5262439 (1993-11-01), Parthasarathy
patent: 5294724 (1994-03-01), Jendralla et al.
patent: 5627205 (1997-05-01), Regnier et al.
patent: 5770355 (1998-06-01), Brocia
patent: 6121319 (2000-09-01), Somers
patent: 6147250 (2000-11-01), Somers
patent: 6323359 (2001-11-01), Jass
patent: 6448019 (2002-09-01), Mendelsohn et al.
patent: 6548699 (2003-04-01), Somers
patent: 27 16 125 (1977-10-01), None
patent: 190 682 (1986-08-01), None
patent: 212 310 (1987-03-01), None
patent: 254 272 (1988-01-01), None
patent: 292 660 (1988-11-01), None
patent: 317 165 (1989-05-01), None
patent: 348 203 (1989-12-01), None
patent: 405 788 (1991-01-01), None
patent: 418 648 (1991-03-01), None
patent: 621 255 (1994-10-01), None
patent: 763 527 (1997-03-01), None
patent: 2.130.975 (1972-11-01), None
patent: 2.133.024 (1972-11-01), None
patent: 2.134.810 (1972-12-01), None
patent: 2.140.769 (1973-01-01), None
patent: 2.168.137 (1973-08-01), None
patent: 1136539 (1968-12-01), None
patent: 1148550 (1969-04-01), None
patent: 1199871 (1970-07-01), None
patent: WO 9530415 (1995-11-01), None
patent: WO 9612703 (1996-05-01), None
patent: WO 9715546 (1997-05-01), None
patent: WO 9726258 (1997-07-01), None
patent: WO 9822418 (1998-05-01), None
patent: WO 9830255 (1998-07-01), None
patent: WO 9851289 (1998-11-01), None
patent: WO 9851662 (1998-11-01), None
patent: WO 9924400 (1999-05-01), None
patent: WO 0026184 (2000-05-01), None
patent: WO 0028332 (2000-05-01), None
U.S. Appl. No. 09/370,046, filed Aug. 6, 1999, Somers.
U.S. Appl. No. 09/436,892, filed Nov. 9, 1999, Medford et al., (Corrected Amendment and Response to Office Action dated Aug. 17, 2001.
U.S. Appl. No. 09/570,098, filed May 12, 2000, Patricia K. Somers, (Amendment and Response to Office Action dated May 12, 2000).
U.S. Appl. No. 09/779,086, filed Feb. 7, 2001, Chinery et al., (Substitute Specification and Drawings filed Jun. 18, 2001).
U.S. Appl. No. 09/833,407, filed Apr. 11, 2001, Luchoomun et al.
U.S. Appl. No. 10/060,734, filed Jan. 30, 2002, Patricia K. Somers, (Preliminary Amendment Filed Jan. 30, 2002).
U.S. Appl. No. 10/036,307, filed Oct. 25, 2001, Patricia K. Somers et al.
U.S. Appl. No. 10/114,346, filed Apr. 2, 2002, Charles Q. Meng, (Preliminary Amendment Filed Apr. 2, 2002).
U.S. Appl. No. 10/114,351, filed Apr. 2, 2002, Charles Q. Meng, (Preliminary Amendment Filed Apr. 2, 2002).
U.S. Appl. No. 10/115,206, filed Apr. 2, 2002, Charles Q. Meng, (Preliminary Amendment Filed Apr. 2, 2002).
U.S. Appl. No. 10/122,516, filed Apr. 11, 2002, Luchoomun et al.
Chemical Abstract, Database Chemabs Online!, Chemical Abstracts Service, Columbus, Ohio, US, STN, Accession No. 127:75973, XP002115597, see abstract; RN 1706-68-9 & V.Z. Lankin et al.: Dokl. Akad. Nauk, V. 351, No. 4, 1996, pp. 554-557.
Chemical Abstract, Database Chemabs Online!, Chemical Abstracts Service, Columbus, Ohio, US, STN, Accession No. 82:86196, XP002115598, see abstract; RN 54622-23-0, 54622-24-1 & Chemical Abstracts, vol. 82, No. 13, Mar. 31, 1975 (Mar. 1, 1975) Columbus, Ohio, US; Abstract No. 86196, XP002115592 abstract & JP 49 075552 A 9 (Sagami Chemical Research Center) Jul. 20, 1974.
Chemical Abstract, Database Chemabs Online!, Chemical Abstracts Service, Columbus, Ohio, US, STN, Accession No. 124:8690, XP00215603, see abstract; RN 171078-69-6, 171078-70-9, 171078-72-1,171078-73-2, 171078-75-4, 171078-76-5, 171078-77-6, 171078-78-7 & Chemical Abstracts, vol. 124, No. 1, Jan. 1, 1996, Columbus, Ohio, US; Abstract No. 8690, XP002115596 abstract & V.I. Kelarev et al.: Khim. Geterotsikl. Soedin, No. 4, 1995, pp. 514-517.
Chemical Abstract, Database Chemabs Online!, Chemical Abstracts Service, Columbus, Ohio, US, STN, Accession No. 124:146082, XP002115604, see abstract; RN 162933-21-3, 162933-22-4, 162933-23-5, 169180-32-9, 169180-34-1, 169180-36-3,173461-90-0, 173461-82--0, 173461-84-2, 173461-90-0, 173461-93-3, 173461-95-5 & V.I. Kelarev et al.: Khim. Geterotsikl. Soedin, No. 5, 1995, pp. 667-673.
Chemical Abstract, Database Chemabs Online!, Chemical Abstracts Service, Columbus, Ohio, US, STN, Accession No. 110:212254, XP002115683, see abstract; RN 100204-33-9, 111155-56-7, 9434-96-1, 120455-07-4, 120455-08-5, 120455-09-6, 120455-10-9 & Chemical Abstracts, vol. 110, No. 23, Jun. 5, 1989 Columbus, Ohio, US; Abstract No. 212254a, XP002115682 abstract & S.D. Pastor et al.: Phosphorous Sulfur, vol. 37, No. 3-4, 1988, pp. 117-123, L. Cominacini et al.: Free Radical Biology and Medicine, vol. 22, No. 1 -2, 1996, pp. 117-127, XP002095164, see figures 6-7.
Chemical Abstract, Database Chemabs Online!, Chemical Abstracts Service, Columbus, Ohio, US, STN, Accession No. 126:277465, XP002115599, see abstract; 188611-72-5, 188611-74-7, 188611-75-8, 188611-81-6, 188611-82-7 & Chemical Abstracts, vol. 126, No. 21, May 26, 1997 Columbus, Ohio, US; Abstract No. 277465, XP002115593 abstract & JP 09 059258 A (Ono Pharmaceutical Co) (Mar. 4, 1997).
Chemical Abstract, Database Chemabs Online!, Chemical Abstracts Service, Columbus, Ohio, US, STN, Accession No. 94:30290, XP00211560, see abstract; RN 76163-51-4 & CH. I. Mamedov: Mater. Nauchn. Konf. Aspir. Akad. Nauk Az. SSR, vol. 1, 1980, pp. 127-131.
Chemical Abstract, Database Chemabs Online!, Chemical Abstracts Service, Columbus, Ohio, US, STN, Accession No. 86:5066, XP002115601, see abstract; RN 55109-77-8, 61151-55-1 & Chemical Abstracts, vol. 86, No. 1, Jan. 3, 1977 Columbus, Ohio, US; Abstract No. 5066, XP002115594, abstract & A.I. Medvedev et al.: Tezisy Dokl. Nauchn. Sess. Khim. Teknol. Org. Soedin. Sery Sernistykh Neftei, 13th, 1974, pp. 123-124.
Chemical Abstract, Database Chemabs Online!, Chemical Abstracts Service, Columbus, Ohio, US, STN, Accession No. 122:187387, XP002115602, see abstract; RN 161523-77-9, & Chemical Abstracts, vol. 122, No. 15, Apr. 10, 1995 Columbus, Ohio, US; Abstract No. 187387, XP002115595 abstract & JP 06 312978 A (Nippon Tobacco Sangyo et al) Nov. 8, 1994.
Chemical Abstrct, Database Chemabs Online!, Chemical Abstracts Service, Columbus, Ohio, US, STN, CAPLUS Accession No. 1970:445047, XP002124423, see abstract; RN 27428-10-0, 27428-13-3, 27428-14-4, 27428-15-5, 27428-16-6, 27428-17-7, 27428-18-8, 27428-19-9 & M. B. Neuworth et al.: J. Med. Chem., V. 13, No. 4, 1970, pp. 722-725.
Chemical Abstract, Database Chemabs Online!, Chemical Abstracts Service, Columbus, Ohio, US, STN, CAPLUS Accession No. 1986:28675, XP002124424, see abstract; RN 99661-86-6, 99661-87-7, 27466-44-0 & Chemical Abstracts, vol. 104, No. 5, Feb. 3, 1986, Columbus, Ohio, US; Abstract No. 28675, abstract & P. De Meglio et al.: Farmaco, Ed. Sci., vol. 40, No. 11, 1985, pp. 833-844.
Cominacini et al., “Antioxidants Inhibit the Expression of Intercellular Cell Adhesion molecule-1 and Vascular Cell Adhesion Molecule-1 Induced by Oxidized LDL on Human Umbilical Vein Endothelial Cells,”Free Radical Biology&Medicine, vol. 22, Nos. 1/2, pp. 117-127, 1997.
Feldman, Davis, et al., “The In Vitro and Ex Vivo Antioxidant Properties, and Hypolipidemic Activity of CGP 2881,”Atherosclerosis, Dec. 28, 1998, vol. 144, pp. 343-355.
Fruebis, Joachim, “A Comparison of the Antiatherogenic
Hoong Lee K.
Meng Charles Q.
Somers Patricia K.
Atherogenics, Inc.
Barts Samuel
King & Spalding LLP
Knowles, Esq. Sherry M.
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