Thioformamide derivatives

Details Thioformamide derivatives Thioformamide derivatives

1990-01-05

1992-04-14

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514307, 514318, 514340, 514343, 514346, 514357, 514247, 514269, 514255, 514415, 514365, 546146, 546147, 546174, 546175, 546281, 546291, 546330, 546331, 544224, 544335, 544336, 548204, 548469, A61K 3144, A61K 3147, C07D21706, C07D40104

Patent

active

051048833

ABSTRACT:
Thioformamide derivatives of the formula: ##STR1## wherein: R represents alkyl; A represents an optionally substituted phenyl or heteroaromatic group; R.sup.1 represents hydrogen, alkyl, cyano, carboxyl, formyl, carbamoyl, alkoxycarbonyl or a group --(CH.sub.2).sub.n OR.sup.2, --(CH.sup.2).sub.n SR.sup.2, --(CH.sub.2).sub.n N(R.sup.2).sub.2, --CH.dbd.CHR.sup.3, --CH.dbd.NOR.sup.4, --CONHR.sup.5, or --COR.sup.6 ; R.sup.2 represents hydrogen, alkyl, alkanoyl, aryl, aryl (CH.sub.2).sub.n -- or arylCO--, or, when attached to nitrogen, two R.sup.2 groups may together represent alkylene; R.sup.3 represents hydrogen; alkyl, alkanoyl, carboxyl, carbamoyl, cyano, aryl, arylCO--, aryl(CH.sub.2).sub.n --, or aryl (CH.sub.2).sub.n CO--; R.sup.4 represents hydrogen, alkyl, aryl, aryl (CH.sub.2).sub.n -, optionally substituted alkyl, alkenyl, amino or carbamoyl N,N-disubstituted by alkylene; R.sup.5 represents alkyl, aryl, or aryl (CH.sub.2).sub.n -- or an amino acid residue; R.sup.6 represents alkyl, aryl, or aryl (CH.sub.2).sub.n --; represents a single or double bond provided that when R.sup. 1 is formyl represents a double bond; Y represents ethylene, methylene or a direct bond; and n is 1 to 6; and salts thereof possess useful pharmacological properties.

REFERENCES:
Chem. Abstracts; vol. 112, No. 1; 7390s (1990).

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