Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – In an organic compound
Reexamination Certificate
2007-07-26
2010-12-21
Jones, D L (Department: 1618)
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
In an organic compound
C424S001110, C424S001650, C424S001810, C424S001850, C548S146000, C548S152000
Reexamination Certificate
active
07854920
ABSTRACT:
This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising the thioflavin derivatives and method of synthesizing the compounds. The compounds find particular use in the diagnosis and treatment of patients having diseases where accumulation of neuritic plaques are prevalent. The disease states or maladies include but are not limited to Alzheimer's disease, familial Alzheimer's disease, Down's Syndrome and homozygotes for the apolipoprotein E4 allele.
REFERENCES:
patent: 3257204 (1966-06-01), Sus et al.
patent: 4500340 (1985-02-01), Becker et al.
patent: 4540648 (1985-09-01), Scheler
patent: 5935927 (1999-08-01), Vitek et al.
patent: 7270800 (2007-09-01), Klunk et al.
patent: 7351401 (2008-04-01), Klunk et al.
patent: 2003/0236391 (2003-12-01), Klunk et al.
patent: 2 382 406 (2001-03-01), None
patent: 0 081 141 (1981-12-01), None
patent: 0 118 086 (1983-03-01), None
patent: 0 287 909 (1988-10-01), None
patent: 2006-510705 (2006-03-01), None
patent: WO 95/06469 (1995-03-01), None
patent: WO 97/26919 (1997-07-01), None
patent: WO 98/17267 (1998-04-01), None
patent: WO 01/14354 (2001-03-01), None
patent: WO 02/16333 (2002-02-01), None
patent: WO 02/16333 (2002-02-01), None
patent: WO 02/051821 (2002-07-01), None
patent: WO 02/085903 (2002-10-01), None
patent: WO 02/085903 (2002-10-01), None
patent: WO 2004.056399 (2004-07-01), None
Shi et al., “Antitumor Benzothiazoles, 3.1Synthesis of 2-(4-Aminophenyl)benzothiazoles and Evaluation of Their Activities against Breast Cancer Cell Lines in Vitro and in Vivo”,J. Med. Chem., 1996, pp. 3375-3384, vol. 39, The American Chemical Society.
Cuadro et al., “Styryl and Azastyryl 1,3-Benzazoles with Antihelmitic Activity”,II Farmaco, 1992, pp. 477-488, vol. 47, No. 4.
Fokken et al., “Beitrag zur Darstellung von Verbindungen mit Amidino- bzw. Amidoximstruktur”,Pharmazie, 1977, pp. 566-569, Pharmazie 32, H.10 (19).
Grozinger et al., Heterocyclic ethenyloxanilates as orally active antiallergic agents,Eur. J. Med. Chem. Chim. Ther., 1985, pp. 487-491, vol. 20, No. 6.
Dryanska, “α-Hydroxybenzylation and Benzylidenation of the Methyl Group in 2-Methyl-1,3-benzoxazole and 2-Methyl-1,3-benzothiazole” Communications, 1976, pp. 37-38.
Vaz et al., “6-Substituted 2-(p-aminostyryl)benzothiazole derivatives”,Indian J. Chem., 1976, Sect. B, pp. 709-711, vol. 14B, No. 9.
Bogert et al., “Researches on Thiazoles, XVII. An Investigation of the Connection Between Constitution and Color in the Thioflavine Group”, Collection of Czechoslovak Chemical Communications, 1931, pp. 480-498, vol. 3, The Chemical Laboratories.
Martvo{hacek over (n)} et al., “2-Phenyl-6-Benzothiazolyl Isothiocyanates”,Collection Czechoslov, Chem. Commun. 1974, pp. 1356-1365, vol. 39, No. 5.
Klunk et al., “Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain”,Life Sciences, 2001, pp. 1471-1484, vol. 69, No. 13, Elsevier Pub.
Wang et al., “Synthesis and evaluation of a radioiodinated benzothiazole derivative as a radioligand for in vivo quantitation of beta-amyloid deposits in aging and Alzheimer's disease”,Journal of Labelled Compounds and Radiopharmaceuticals, 2001, pp. S239-S241, vol. 44, No. Supp. 1.
Mathis et al., “Lipophilic 11 C-labelled thioflavin-T analogues for imaging amyloid plaques in Alzheimer's disease”,Journal of Labelled Compounds and Radiopharmaceuticals, 2001, pp. S26-S28, vol. 44, No. Supp. 1.
Zhuang et al., “Radioiodinated Styrylbenzenes and Thioflavins as Probes for Amyloid Aggregates”, Journal of Medical Chemistry, vol. 44, No. 12, 2001, pp. 1905-1914.
Yanming Wang et al., “Synthesis and Evaluation of 2-(3'-lodo-4'-aminophenyl)-6-hydroxybenzothiazole for in Vivo Quantification of Amyloid Deposits in Alzheimer's Disease”, Journal of Molecular Neuroscience, vol. 19, 2002, pp. 11-14.
Chester A. Mathis et al., “A Lipophilic Thioflavin-T Derivative for Positron Emission Tomography (PET) Imaging of Amyloid in Brain”, Bioorganic & Medicinal Chemistry Letters, 12 (2002), pp. 295-298.
Chester A. Mathis et al., “Synthesis and Evaluation of 11C-Labeled 6-Substituted 2-Arylbenzothiazoles as Amyloid Imaging Agents”, J. Med. Chem. 2003, 46, pp. 2740-2754.
Non Final Office Action dated Mar. 13, 2009 for U.S. Appl. No. 12/046,070.
U.S. Appl. No. 12/046,070 Final Office Action Dated Sep. 9, 2009.
Canadian Office Action dated Oct. 7, 2009 for Application No. 2 419 420.
Notice of Reasons for Rejection Japanese Patent Application No. 2006-507179 dated Jul. 13, 2010.
Yanming Wang et al., “Synthesis and Evaluation of 2-(3'-lodo-4'-aminophenyl)-6-hydroxybenzothiazole for In Vivo Quantitation of Amyloid Deposits in Alzheimer's Disease”, Journal of Molecular Neuroscience, vol. 19, 2002, pp. 11-16.
Chester A. Mathis et al., “A Lipophilic Thioflavin-T Derivative for Positron Emission Tomography (PET) Imaging of Amyloid in Brain”, Bioorganic & Medicinal Chemistry Letters, 12 (2002) 295-298.
Chemical Journal of Chinese Universities, 2002 vol. 23 No. 9, pp. 1772-1775. (non-English document).
ZH. Obshch. Khim., 1950, vol. 20, pp. 1807-1815. (non-English document).
Klunk William E.
Mathis, Jr. Chester A.
Wang Yanming
Bent Stephen A.
Foley & Lardner LLP
Jones D L
University of Pittsburgh
LandOfFree
Thioflavin derivatives for use in antemortem diagnosis of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Thioflavin derivatives for use in antemortem diagnosis of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Thioflavin derivatives for use in antemortem diagnosis of... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4232954