Thioether-containing metal chelating compounds

Details Thioether-containing metal chelating compounds Thioether-containing metal chelating compounds

1997-07-07

1999-08-03

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Radioactive metal containing

534 14, 534 16, 424 165, 424 169, 424 9365, 564501, 568 38, 568 43, 568 57, C07F 500, A61K 5104, C07C32100, C07C31900

Patent

active

059327073

ABSTRACT:
Ligands for radiopharmaceutical use are capable of chelating radiometal species and of being bound to biological targeting molecules. The ligands have the formula (a) and (b), where A, A'=--SZ or Y, B=O or S, Y=(c), Z=H or a thiol protecting group, m=2 or 3, n=2 or 3, q=0 or 1, R=H or unsubstituted or substituted hydrocarbon and pharmaceutically acceptable salts, provided that at least one CR.sub.2 group represents CO and forms, together with an adjacent N atom; a --CONR-- amide group. ##STR1##

REFERENCES:
patent: 5112953 (1992-05-01), Gustavson et al.
patent: 5187264 (1993-02-01), Verbruggen
patent: 5387692 (1995-02-01), Riley et al.
Brandau et al., "Tc-99m Diaminomercapto(thio)ethers--A new class of Potential Renal Function Imaging Agents" Proceedings of the 39.sup.th Annual Meeting, J. of Nucl. Med., vol. 33, No. 5, Abs. No. 401, May 1992.

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