Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Chemical modification or the reaction product thereof – e.g.,...
Reexamination Certificate
2006-07-18
2006-07-18
Zemel, Irina (Department: 1711)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Chemical modification or the reaction product thereof, e.g.,...
C530S404000, C530S408000, C514S002600, C514S012200, C525S054100, C525S054200, C525S398000, C525S400000, C525S437000, C525S535000, C525S539000
Reexamination Certificate
active
07078496
ABSTRACT:
The invention provides reagents and methods for conjugating a polymer specifically to the α-amine of a polypeptide. The invention provides monofunctional, bifunctional, and multifunctional PEGs and related polymers having a terminal thioester moiety capable of specifically conjugating to the α-amine of a polypeptide having a cysteine or histidine residue at the N-terminus. The invention provides reactive thioester-terminated PEG polymers that have suitable reactivity with an N-terminal cysteine or histidine residue of a polypeptide to produce an amide bond between the PEG molecule and the polypeptide.
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Fang Zhihao
Roberts Michael J.
Alston & Bird LLP
Nektar Therapeutics AL, Corporation
Zemel Irina
LandOfFree
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