Thioester inhibitors of serine proteases

Details Thioester inhibitors of serine proteases Thioester inhibitors of serine proteases

1983-05-09

1986-04-29

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

558254, 544 90, 544 2, 544 12, 544286, 549399, 549 15, 549 28, 549 17, C07C153023, A61K 31265

Patent

active

045857938

ABSTRACT:
Certain novel heterocyclic compounds, aromatic thioesters, their preparation, and their use in inhibiting serine proteases with chymotrypsin-like and elastase-like specificity and in the treatment of diseases such as emphysema which involve tissue proteolysis.

REFERENCES:
patent: 4256761 (1981-03-01), Suh et al.
Powers, Proteolytic Enzymes and Their Active-Site-Specific Inhibitors: Role in Treatment of Disease, pp. 347-367.
Powers, Synthetic Elastase Inhibitors: Prospects for Use in Treatment of Emphysema, pp. S54-S58.
Teshima et al., Journ. Biological Chem., vol. 257, No. 9, May 10, pp. 5085-5091, 1982.
Alazard et al., Biochimica et Biophysica Acta, 309, (1973), pp. 379-390.

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