Thioester enantiomeric compounds and their therapeutic uses

Details Thioester enantiomeric compounds and their therapeutic uses Thioester enantiomeric compounds and their therapeutic uses

1993-02-01

1994-07-19

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

A61K 3121

Patent

active

053310080

ABSTRACT:
The (R) or (S) isomer of acetorphan or N-/(acetylthiomethyl)-2-oxo-1-phenyl-3-propyl/(S) alanine methyl ester is prepared by splitting of racemic acetylthio-3-benzyl-2-propanoic acid by reaction with ephedrin, separation of the enantiomeric salt obtained, then freeing of the acid and coupling with the corresponding amino acid ester. The obtained preparations possess remarkable therapeutic activities and can notably be used as drugs.

REFERENCES:
patent: 4513009 (1985-04-01), Roques et al.
Goodman Gilman et al. (Editors), Goodman and Gilman's The Pharmacological Basis of Therapeutics (6th Ed.), New York, 1980, MacMillan, pp. 656-659, 819, and 869-873.

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