Thiodepsipeptide isolated from a marine actinomycete

Details Thiodepsipeptide isolated from a marine actinomycete Thiodepsipeptide isolated from a marine actinomycete

1997-09-24

1998-12-15

Achutamurthy, Ponnathapura

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using a micro-organism to make a protein or polypeptide

435 712, 435 711, 435 52, C12P 2100

Patent

active

058495401

ABSTRACT:
The present invention is directed to a novel depsipeptide has been isolated from a new marine strain L-13-ACM2-092 belonging to the family Micromonosporaceae. Its production by aerobic fermentation under controlled conditions of the strain, and the isolation and purification of PM-93135 are described herein. The compound and the fermentation broth demonstrate significant activity against several cancer cell lines. The compound also shows activity against several gram positive bacteria.

REFERENCES:
patent: 4366309 (1982-12-01), Ganguly et al.
Otsuka et al, The Journal of Antibiotics, Ser. A. pp. 128-131, (May, 1966).
Williamson, et al, the Journal of Antibiotics, vol. XXXV(1), pp. 62-66 (Jan. 1982).
Yoshida et al, Journal of Bacteriology, vol. 93(4), PP. 1327-1331, (1967).
Bergeron et al, Biochemical and Biophysical Res. Comm., vol. 121 (3), pp. 848-854 (Jun. 29, 1984).
Okada et al, The Journal of Antibiotics, vol. 47(2), PP. 129-135, (1994).

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