Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1994-04-06
1997-10-28
Achutamurthy, Ponnathapura
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 9, 514 2, 530317, A61K 3815, C07K 1102
Patent
active
056818130
ABSTRACT:
The present invention is directed to a novel depsipeptide has been isolated from a new marine strain L-13-ACM2-092 belonging to the family Micromonosporaceae. Its production by aerobic fermentation under controlled conditions of the strain, and the isolation and purification of PM-93135 are described herein. The compound and the fermentation broth demonstrate significant activity against several cancer cell lines. The compound also shows activity against several gram positive bacteria.
REFERENCES:
patent: 4366309 (1982-12-01), Ganguly et al.
Otsuka et al, The Journal of Antibiotics, Ser. A, pp. 128-131, (May. 1966).
Williamson et al, The Journal of Antibiotics, vol. XXXV (1), pp. 62-66, (Jan. 1982).
Yoshida et al, Journal of Bacteriology, vol. 93(4), pp. 1327-1331, (1967).
Bergeron et al, Biochemical and Biophysical Res. Comm., vol. 121(3), pp. 848-854, (Jun. 29, 1984).
Okada et al., The jOurnal of Antibiotics, vol. 47, No. 2 pp. 129-135 (1994) .
Baz Julia Perez
De Quesada Teresa Garcia
Garcia Gravalos Dolores
Millan Francisco Romero
Achutamurthy Ponnathapura
Linek Ernest V.
Pharma Mar S.A.
Wessendorf T. D.
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