Thiocarboxamide derivatives and their use as pharmaceuticals

Details Thiocarboxamide derivatives and their use as pharmaceuticals Thiocarboxamide derivatives and their use as pharmaceuticals

1981-05-18

1983-04-05

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424251, 424258, 424263, 424273R, 544238, 544283, 544335, 544336, 544353, 546122, 546176, 546268, 546283, 546284, 548336, A61K 3150, C07D23708

Patent

active

043791549

ABSTRACT:
Thioformamide derivatives of the formula: ##STR1## wherein R represents hydrogen or alkyl of 1 through 4 carbon atoms, and (i) Het represents a heterocyclic radical selected from pyrid-3-yl, pyrid-4-yl, pyridazinyl, pyrazinyl, pyrimidinyl, quinolyl, imidazolyl, naphthyridinyl, quinoxalinyl and quinazolinyl, X represents sulphur or oxygen and Y represents sulphur or oxygen, a valency bond or methylene, or (ii) Het represents pyrid-2-yl, X represents sulphur or oxygen and Y represents sulphur or oxygen or methylene, or (iii) Het represents pyrid-2-yl, X represents oxygen and Y represents a valency bond, are new compounds possessing useful pharmacological properties. They are particularly useful in the treatment of gastrointestinal ulcers and in the treatment of hypertension, depending on the definition of the symbol Het.

REFERENCES:
patent: 4272534 (1981-06-01), Aloup et al.

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