Thiocarbamates

Details Thiocarbamates Thiocarbamates

1977-02-28

1978-08-29

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

2602071, A61K 31655, C09B 2500

Patent

active

041104447

ABSTRACT:
The disclosure is directed to mono- and dithiocarbamates (hereinafter thiocarbamates) corresponding to the formula RNHCXSR'COOR" wherein R is paraphenylazophenyl or metafluorophenyl, X is oxygen when R is paraphenylazophenyl and X is sulfur when R is metafluorophenyl, R' is an alkylene radical having generally from 1 to about 5 carbon atoms and R" is hydrogen or an alkyl radical having generally from 1 to about 10 carbon atoms. The thiocarbamates, in acid form, can be prepared by blocking the carboxyl group of a mercaptoalkanoic acid with a carboxyl blocking agent; interacting the carboxyl blocked, mercaptoalkanoic acid with paraphenylazophenyl isocyanate or metafluorophenyl isothiocyanate to produce a thiocarbamate reaction product; and treating the thiocarbamate reaction product to remove the carboxyl blocking agent and to obtain the product in carboxylic acid form. The thiocarbamates, in ester form, can be prepared by interacting an alkyl mercaptoalkanoate with paraphenylazophenyl isocyanate or metafluorophenyl isothiocyanate. The thiocarbamates possess the unique property of being able to modify and enhance the strength of biological membranes.

REFERENCES:
patent: 3097198 (1963-07-01), Fishwick et al.

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