Thio-ester of 1 (p-chlorobenzoyl)-5-methoxy-2-methylindole-3-ace

Details Thio-ester of 1 (p-chlorobenzoyl)-5-methoxy-2-methylindole-3-ace Thio-ester of 1 (p-chlorobenzoyl)-5-methoxy-2-methylindole-3-ace

1976-11-29

1978-10-10

Love, Ethel G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424274, C07D20904

Patent

active

041196384

ABSTRACT:
This invention relates to a new class of compounds of the indole series. Particularly, it relates to novel thio esters of 1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid. These novel compounds are prepared by reacting 1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid with an appropriate thiol and diethyl phosphorocyanidate or diphenyl phosphorazidate in the presence of triethylamine in a dimethylformamide solution. These compounds are useful anti-inflammatory agents.

REFERENCES:
patent: 3161654 (1964-12-01), Shen
patent: 3522272 (1970-07-01), Chemerda et al.
patent: 3691199 (1972-09-01), Kobaysahi et al.
patent: 3894044 (1975-07-01), Sturm et al.
Chem. Abstracts, 1947-1956-Subject Index, 6568s-6569s.
Chem. Abstracts, 50:2543h.

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