Thin-layer chromatographic method for the separation of enantiom

Details Thin-layer chromatographic method for the separation of enantiom Thin-layer chromatographic method for the separation of enantiom

1984-07-25

1986-05-20

Adee, John

Chemistry: analytical and immunological testing

Including chromatography

Utilizing paper or thin layer plate

210658, B01D 1508

Patent

active

045901678

ABSTRACT:
Thin-layer chromatography is employed to separate enantiomers of the general formula, ##STR1## in which C* represents an asymmetric center and the substituents R.sup.1, R.sup.2, and R.sup.3 are such that they supply the structural element ##STR2## for .alpha.-amino- or .alpha.-iminocarboxylic acids, particularly the well-known .alpha.-amino- or .alpha.-iminocarboxylic or for derivatives of such carboxylic acids, either of which contains no free thiol groups. In the thin-layer chromatographic separation operation a TLC plate is used which is coated with silica gel hydrophobicized by a silane derivative and which is further impregnated with an ionic compound of a divalent transition metal and a chiral selector. The mobile phase employed is a ternary mixture of a water-miscible alkanol, such as methanol, water, and acetonitrile, or a quaternary mixture of the latter ternary mixture to which a water-miscible cyclic ether, such as tetrahydrofuran, has been added.

REFERENCES:
patent: 3647684 (1972-03-01), Malcomb
patent: 4415631 (1983-11-01), Schutijser
patent: 4431546 (1984-02-01), Hughes et al.
patent: 4469875 (1984-09-01), Busker et al.
Ligand Chromatography and the Preparation of Optically Active Compounds by Davankov Soviet Science Review, vol. 3, No. 6, Nov. 1972, pp. 352-356.
Resolution of the Optical Isomers of Dansyl Amino Acids by Reverse Phase Liquid Chromatography with Optically Active Metal Chelate Additives by Page et al., Analytical Chemistry, vol. 51, No. 3, Mar. 1979, pp. 433-435.

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