Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form
Patent
1998-02-20
1999-09-28
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
424422, 424423, 424426, A61K 900, A61F 1300, A61F 200
Patent
active
059584300
ABSTRACT:
The invention provides a thin-film composition comprising an underlying substrate of a first material including a plurality of attachment sites; a plurality of functional groups chemically attached to the attachment sites of the underlying substrate; and a thin film of a second material deposited onto the attachment sites of the underlying substrate, and a biologically active substance deposited with the thin-film. Preferably the functional groups are attached to a self assembling monolayer attached to the underlying substrate. Preferred functional groups attached to the underlying substrate are chosen from the group consisting of carboxylates, sulfonates, phosphates, optionally substituted, linear or cyclo, alkyl, alkene, alkyne, aryl, alkylaryl, amine, hydroxyl, thiol, silyl, phosphoryl, cyano, metallocenyl, carbonyl, and polyphosphate. Preferred materials for the underlying substrate are selected from the group consisting of a metal, a metal alloy, a plastic, a polymer, a proteic film, a membrane, a glass or a ceramic. The second material is selected from the group consisting of inorganic crystalline structures, inorganic amorphus structures, organic crystalline structures, and organic amorphus structures. Preferred second materials are phosphates, especially calcium phosphates and most particularly calcium apatite. The biologically active molecule is a protein, peptide, DNA segment, RNA segment, nucleotide, polynucleotide, nucleoside, antibiotic, antimicrobal, radioisotope, chelated radioisotope, chelated metal, metal salt, anti-inflamatory, steriod, nonsteriod anti-inflammatory, analgesic, antihistamine, receptor binding agent, or chemotherapeutic agent, or other biologically active material. Preferably the biologically active molecule is an osteogenic factor the compositions listed above.
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Rieke, P., et al, Biomimetic Thin-Film Synthesis, American Chemical Society Symposium, 1992, Series No. 499, Chapter 6, 61-75.
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Campbell Allison A.
Song Lin
Battelle (Memorial Institute)
Channavajjala Lakshmi
Page Thurman K.
Zimmerman Paul W.
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