Thimerosal inactivated mycoplasma hyopneumoniae vaccine

Details Thimerosal inactivated mycoplasma hyopneumoniae vaccine Thimerosal inactivated mycoplasma hyopneumoniae vaccine

1992-05-29

1994-08-16

Knode, Marian

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

4352521, 435870, 424825, A61K 3902

Patent

active

053385438

ABSTRACT:
The invention relates to a method for making an inactivated vaccine of Mycoplasma hyopneumoniae by inactivating the bacteria with Thimerosal. The resulting bacterin is mixed with an adjuvant of aluminum hydroxide and DEAE dextran and injected into pigs. The resulting bacterin and adjuvant mixture can also be mixed with other bacteria such as Borderella and Pasteurella, for further adjuvant effect. Protective immunity against mycoplasmal pneumonia is elicited in swine using these vaccines.

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Gupta, R et al., "Effects of Elevated Temperatures on the Opacity and Toxicity of Pertussis Vaccines Manufactured with Different Inactivating Agents", Biological Abstracts 82(11): 102519 1986.
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