Thienyl-, furyl- and pyrrolyl sulfonamides and derivatives there

Details Thienyl-, furyl- and pyrrolyl sulfonamides and derivatives there Thienyl-, furyl- and pyrrolyl sulfonamides and derivatives there

1995-06-06

1997-01-14

McKane, Joseph

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514311, 514312, 514313, 514314, 514337, 514338, 514340, 514361, 514362, 514363, 514365, 514369, 514370, 514372, 514379, 514380, 546153, 546155, 546159, 546162, 546167, 546172, 5462721, 548127, 548146, 548182, 548190, 548202, 548203, 548205, 548206, 548213, 548214, 548241, 548243, 548244, 548245, 544367, 544238, A61K 3142, C07D26110

Patent

active

055940218

ABSTRACT:
Thienyl-, furyl- and pyrrolyl-sulfonamides and methods for modulating or altering the activity of the endothelin family of peptides are provided. In particular, N-(isoxazolyl)thienylsulfonamides, N-(isoxazolyl)furylsulfonamides and N-(isoxazolyl)pyrrolylsulfonamides and methods using these sulfonamides for inhibiting the binding of an endothelin peptide to an endothelin receptor by contacting the receptor with the sulfonamide are provided. Methods for treating endothelin-mediated disorders by administering effective amounts of one or more of these sulfonamides or prodrugs thereof that inhibit or increase the activity of endothelin are also provided.

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