Thienyl-containing fatty acid glycosyl phosphatidylinosital anal

Details Thienyl-containing fatty acid glycosyl phosphatidylinosital anal Thienyl-containing fatty acid glycosyl phosphatidylinosital anal

1997-12-15

1999-12-07

Carr, Deborah D

Organic compounds -- part of the class 532-570 series

Organic compounds

Fatty compounds having an acid moiety which contains the...

554218, 554219, 554220, 554223, 514557, 514558, 514559, 514560, 514568, 562465, 562470, C07C 5958

Patent

active

059986425

ABSTRACT:
A method of inhibiting parasitic activity is disclosed in which the biosynthesis, structure and/or function of the glycosyl phosphatidylinositol (GPI) anchor of said parasite may be affected by incorporating into said GPI anchor selected analogs of myristic acid containing various heteroatoms, substituents and unsaturated bonds, including ester-containing analogs, ketocarbonyl-containing analogs, sulfur-containing analogs, double bond- and triple bond-containing analogs, aromatic moiety-containing analogs, nitrated analogs and halogenated analogs.

REFERENCES:
patent: 5151445 (1992-09-01), Welply et al.
Doering et al, Proc. Natl. Acad. Sci, vol. 91, pp. 9735-9739, 1994.
Doering et al., Science 252, 1851-1854 (1991).
Low, Biochem. J. 244, 1-13 (1987).
Ferguson, Science 239, 753-759 (1988).
Ferguson & Cross, J. Biol. Chem. 259, 3011-3015 (1984).
Ferguson et al., Ibid. 260, 4963-4968 (1985).
Heuckeroth et al., J. Biol. Chem. 263, 2127-2133 (1988).
Heuckeroth et al., Proc. Natl. Acad. Sci. USA 85, 8795-8799 (1988).
Heuckeroth et al., Proc. Natl. Acad. Sci. USA 86, 5262-5266 (1989).
Bryant, et al., Proc. Natl. Acad. Sci. USA 86, 8655-8659 (1989).
Kishore et al., J. Biol. Chem. 266, 8835-8855 (1991).
Devadas et al., J. Biol. Chem. 267, 7224-7293 (1992).
Gokel et al., Israel J. Chem. 32, 127-133 (1992).
Rudnick et al., Proc. Natl. Acad. Sci. 89, 10507-10511 (1992).
Lu et al., J. Biol. Chem. 269, 5346-5357 (1994).

Affiliated with

Also associated with

Rating

Thienyl-containing fatty acid glycosyl phosphatidylinosital anal does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Thienyl-containing fatty acid glycosyl phosphatidylinosital anal, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Thienyl-containing fatty acid glycosyl phosphatidylinosital anal will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-825615