Thienyl benzothienyl and dibenzothienyl compounds as inhibitors

Details Thienyl benzothienyl and dibenzothienyl compounds as inhibitors Thienyl benzothienyl and dibenzothienyl compounds as inhibitors

1989-04-28

1992-04-07

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549 42, 549 45, 549 47, 549 50, 549 52, 549 54, 549 55, 549 61, 549 62, 549 63, 549 64, 549 65, 549 66, 549433, 549435, 549436, 549438, 549439, 549440, 549460, 549467, 549474, 549476, 548421, 548429, 548443, 548453, 548473, 548476, 548477, 548567, 514411, 514418, 514424, 514425, 514445, 514463, 514464, 514469, 514471, 514473, A61K 3138, C07D33352

Patent

active

051029057

ABSTRACT:
The invention concerns heterocyclic nitromethane derivatives of the formula 1 as defined hereinafter (and their non-toxic salts) wherein the heterocyclic moiety Q is thienyl, benzothienyl or dibenzothienyl and may bear a wide variety of optional substituents, together with pharmaceutical compositions containing them. The nitromethane derivatives are inhibitors of the enzyme aldose reductase and are of value in the treatment of certain complications of diabetes and galactosemia.

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