Thienothiazine derivatives and their use

Details Thienothiazine derivatives and their use Thienothiazine derivatives and their use

1994-02-18

1996-06-18

Geist, Gary

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544 48, A61K 3138, C07D51304

Patent

active

055277969

ABSTRACT:
Thienothiazine derivatives of the formula ##STR1## in which X denotes a single bond, a straight chain or branched carbon chain having 1-12 C-atoms in the chain, it being possible for this chain to contain one or more double or triple bonds and/or two or more heteroatoms, Y denotes a single bond, and R denotes a monocyclic or polycyclic, optionally partly hydrogenated aryl, heteroaryl, arlyoxy, arylaza, heteroarylaza, arylthio or heteroarylthio radical which can optionally be substituted by lower alkyl, mono- or poyhalogenated lower alkyl, perfluorinated lower alkyl, alkoxy or halogen, and their use.

REFERENCES:
patent: 4076709 (1978-02-01), Hromatka et al.
patent: 4090020 (1978-05-01), Binder et al.
patent: 4180662 (1979-12-01), Pfister et al.
patent: 4187303 (1980-02-01), Hromatka et al.
patent: 4224445 (1980-09-01), Hromatka et al.
Tanaka et al., Structure-Activity Relationships of the Thienothiazine Derivatives with Their Antiinflammatory, Analgesic and Ulcerogenic Effects and Their Inhibitory Effects on PGE.sub.2 Biosynthesis, Chemical Abstracts 111:166771n (1989).
Hitzenberger et al., Pharmacokinetics of Lornoxicam in Man, Chemical Abstracts 115:21532h (1991).

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