Thienoquinolizines and their use as .alpha..sub.2 -adrenoceptor

Details Thienoquinolizines and their use as .alpha..sub.2 -adrenoceptor Thienoquinolizines and their use as .alpha..sub.2 -adrenoceptor

1985-08-12

1987-02-03

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 80, A61K 3138, C07D45504

Patent

active

046409246

ABSTRACT:
The invention concerns thienoquinolizines of general formula (I) ##STR1## and their pharmaceutically acceptable acid addition salts. In the formula R.sup.1 is hydrogen or lower alkyl and R.sup.2 is lower alkyl, halo(lower)alkyl, --A--NR.sup.3 R.sup.4 [where A represents a direct bond between the S and N atoms or a lower alkylene group having 1 to 3 carbon atoms in the chain between the S and N atoms and R.sup.3 and R.sup.4 each independently represent hydrogen, lower alkyl, aryl or aryl(lower)alkyl or together with the nitrogen atom to which they are attached represent a five or six membered heterocyclic ring], aryl or a heterocyclic radical or R.sup.1 is --A.sup.1 NR.sup.5.SO.sub.2 R.sup.6 [where A.sup.1 is a lower alkylene group having 1 to 3 carbon atoms in the chain between the two N atoms, R.sup.5 is hydrogen or lower alkyl and R.sup.6 is lower alkyl, halo(lower)alkyl or aryl] and R.sup.2 is lower alkyl, halo(lower)alkyl or aryl. The compounds possess .alpha..sub.2 -adrenoceptor antagonistic activity in warm blooded animals.

REFERENCES:
patent: 4060619 (1977-11-01), Philipp et al.
patent: 4454139 (1984-06-01), Ward et al.
patent: 4473572 (1984-09-01), Ward
patent: 4481200 (1984-11-01), Ward et al.
patent: 4526967 (1985-07-01), Ward

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