Thienopyrimidines, process for preparing the same and use...

Details Thienopyrimidines, process for preparing the same and use... Thienopyrimidines, process for preparing the same and use...

2003-01-29

2009-08-04

Coleman, Brenda L (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S278000

Reexamination Certificate

active

07569570

ABSTRACT:
The present invention provides a thienopyrimidine compound, represented by the formula[wherein, R1is C1-4alkyl, R2is (1) phenyl optionally having a substituent such as amino, mono C1-4alkylamino and di C1-4alkylamino, or (2) a heterocyclic group optionally having a substituent such as amino, mono C1-4alkylamino and di C1-4alkylamino and the like, R3is a hydrogen atom or C1-4alkyl, R4is C1-4alkyl optionally having a substituent such as C1-4alkoxy-carbonyl, carboxyl, mono C1-4alkylamino and N—C1-4alkyl-N—C7-10aralkylamino and the like] or a salt thereof, which has antagonistic action for gonadotropin-releasing hormone.

REFERENCES:
patent: 5817819 (1998-10-01), Furuya et al.
patent: 6048863 (2000-04-01), Furuya et al.
patent: 6262267 (2001-07-01), Furuya et al.
patent: 6297255 (2001-10-01), Furuya et al.
patent: 6297379 (2001-10-01), Furuya et al.
patent: 6329388 (2001-12-01), Furuya et al.
patent: 6340686 (2002-01-01), Furuya et al.
patent: 2003/0134863 (2003-07-01), Furuya et al.
patent: 2003/0176360 (2003-09-01), Igari et al.
patent: 2004/0034039 (2004-02-01), Nakano et al.
patent: 1266898 (2002-12-01), None
patent: 1291023 (2003-03-01), None
patent: 09208496 (1997-08-01), None
patent: 2003026601 (2003-01-01), None
Jones et al, “British Society of Gastroenterology guidelines for the management of the irritable bowel syndrome.” Gut 2000, (Suppl II)47:ii1-ii19.
S. Sasaki, et al., “Discovery of a Thieno[2,3-d]pyrimidine-2,4-dione Bearing a p-Methoxyureidophenyl Moiety at the 6-Position: A Highly Potent and Orally Bioavailable Non-Peptide Antagonist for the Human Luteinizing Hormone-Releasing Hormone Receptor”, J. Med. Chem. (2003), pp. 113-124, vol. 46.

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