Thienopyrimidines as cooling agents

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Reexamination Certificate

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07615560

ABSTRACT:
Use of a compound of formula (I) where R1is a C4-6alkylene linkage optionally substituted by a C1-4alkyl group; R2is ═NH, —NH2or —OH; R3is C1-5alkyl optionally terminated by a hydroxy, phenyl or a 5- or 6-membered heterocyclic group such as furyl or N-imidazolyl and R4is H; or R3and R4together form a C3-5alkylene linkage; to produce a topical refreshing or cooling sensation in a mammal such as a human.

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Search Report Application No. GB 0426266.3 under Section 17 dated Apr. 8, 2005.
Abstract XP002365034 Beilstein Institut Zur Forderung der Chemischen Wissenschaften and Z.A. Hozien et al.: “Synthesis of some biologically active agents derived from thieno′2,3-dpyrimidine derivatives” vol. 52, No. 10, 1997, pp. 753-758.
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