Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-10-18
2011-12-06
O Dell, David K (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C514S301000
Reexamination Certificate
active
08071776
ABSTRACT:
The present invention relates to selective allosteric potentiators of the Formula (I):or pharmaceutically acceptable salts thereof, for the treatment of disorders associated with M4muscarinic receptors.
REFERENCES:
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patent: WO 01/83472 (2001-11-01), None
Krejci, A. et. al. “Regulation of signal transduction at M2 muscarinic receptor.” Physiological Research 2004 53(Suppl. 1), S131-S140.
Newell, Kelly A et. al. “Opposing short- and long-term effects on muscarinic M1/4 receptor binding following chronic phencyclidine treatment.” Journal of Neuroscience Research, 2007, 85(6) 1358-1363.
Rhea E. Steinpreis “The behavioral and neurochemical effects of phencyclidine in humans and animals: some implications for modeling psychosis” Behavioural Brain Research 1996, 74, 45-55.
Le Bars, et. al. “Animal Models of Nociception” Pharmacological Reviews 2001, 53, 597-652.
Gomeza, Jesus et. al.. “Generation and pharmacological analysis of M2 and M4 muscarinic receptor knockout mice.” Life Sciences, 2001, 68(22/23), 2457-2466.
Bymaster, F.P. et al., “Muscarinic mechamisms of antipsychotic atypicality”,Progress in Neuro-Psychopharmacology&Biological Psychiatry, vol. 27, pp. 1125-1143 (2003).
Esteban Almudena Rubio
Hilliard Darryl Wayne
Dell David K O
Demeter John C.
Desai Manisha A.
Eli Lilly and Company
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