Thienopyridine and furopyridine kinase inhibitors

Details Thienopyridine and furopyridine kinase inhibitors Thienopyridine and furopyridine kinase inhibitors

2007-04-10

2007-04-10

Desai, Rita (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S299000

Reexamination Certificate

active

10899168

ABSTRACT:
Compounds having the formulaare useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

REFERENCES:
patent: 3470183 (1969-09-01), Roth et al.
patent: 2001/0044538 (2001-11-01), Cheng et al.
patent: 2002/0004511 (2002-01-01), Luzzio et al.
patent: 2002/0013354 (2002-01-01), Cheng et al.
patent: 2002/0151544 (2002-10-01), Hayakawa et al.
patent: 0 438 261 (1991-07-01), None
patent: 97/13771 (1997-04-01), None
patent: 00/39108 (2000-06-01), None
patent: 01/19828 (2001-03-01), None
patent: 03/22852 (2003-03-01), None
patent: 2004100947 (2004-11-01), None
Abdelraek et al., “Synthesis of novel thieno[2,3-d]pyrimidine, thieno[2,3-b]pyridine and thiazolo[3,2-a]pyrimidine derivates and their effect on the production of mycotoxins”, Arch. Pharm. (Weinheim) 325:301-305 (1992).
Abdelrazek et al., “Heterocyclic synthesis with nitriles: a new approach to thiophene and tieno-[2,3-d]-pyrimidine derivates”, Journal f. prakt. Chemie. Band 330(4):585-589 (1988).
Abdelrazek et al., “Heterocyclic synthesis with nitriles: a novel synthesis of some thiophene and thieno[2,3-d]pyrimidine derivates, II [1]”, Z. Naturforsch, B.: Chemical Sci. 44(4):488-492 (1989).
Abdelrazek et al., “Heterocyclic synthesis with nitriles: synthesis of some new thiophene and thieno[2,3-d]pyrimidine derivates IV”, Phosphorus, Sulfur, and Silicon 1:271-277 (1996).
Abdelrazek et al., “Heterocyclic Synthesis with Nitriles: synthesis of some novel thiophene and thieno[2,3-d]pyrimidine derivates”, Phosphorus. Sulfur, and Silicon 71:93-97 (1992).
Dave et al., “Gold-Jacob type of reaction in the synthesis of thieno[3,2-e]pyrimido{1,2-c]pyrimidines: a comparison of classical heating vs solvent-free microwave irradiation”, Heterocycles 51(8):1819-1826 (1999).
Kandeel et al., “Nitriles in heterocyclic synthesis: a novel synthesis of some thieno[2,3-d]pyrimidine and thieno[2,3-b]pyridine derivates”, Heteroatom Chemistry 7(1):29-33 (1996).
Nelson et al., “Dicyclic and Tricyclic Diaminopyrimidine derivates as potent inhibitors of cryptosporidium parvum dihydrofolate reductase: structure-activity and structure-selectivity correlations”, Antimicrobial Agents and Chemotherapy 45(12):3293-3303 (2001).
Rosowsky et al., “2,4-diaminothieno[2,3-d]pyrimidines as antifolates and antimalarials. 3. Synthesis of 5,6-disubstituted deriviates and related tetracyclic analogs”, Journal of Medicinal Chemistry 16(3):191-194 (1973).
Roth et al., “2,4-diaminopyrimidines. The cyclization of 6-phenacylthio and related derivates to thieno[2,3-d]pyrimidines and thiazolo[3,2-c]pyrimidines”, J Med. Chemical 12(2):227-232 (1969).
Roth et al., “The protonation of 2,4-diaminopyrimidines. I. Dissociation constants and substituent effects”, J. Organic Chemical 34(4):821-836 (1969).
Sherif et al., “Syntheses with heterocyclic beta-enaminonitriles: an expeditious synthetic approach to polyfunctionally substituted 5-phenyl-sulfonylthiophenes and their fused derivates”, Monatshefte fur Chemie 128:687-696 (1997).
Taylor et al., “Synthesis of thieno[2,3-d]pyrimidine analogues of the potent antitumor agentN-{4-[2-[(2-amino-4(3H)-oxo-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]-benzoyl}-1-glutamic acid (LY231514),” Heterocycles 43(2):349-365 (1996).

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