Thienoimidazole derivatives, their production and use

Details Thienoimidazole derivatives, their production and use Thienoimidazole derivatives, their production and use

1993-08-27

1995-10-31

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

514393, A61K 31415, C07D23502

Patent

active

054630738

ABSTRACT:
Benzimidazole derivatives of the formula (I): ##STR1## wherein the ring A is a thiophene ring which may optionally contain substitution in addition to the R.sup.3 group; R.sup.1 is hydrogen or an optionally substituted hydrocarbon residue which may be bonded through a heteroatom; R.sup.2 and R.sup.3 are independently a group capable of forming an anion or a group convertible thereinto; X is a direct bond or a spacer having an atomic length of two or less between the phenylene group and the phenyl group; and n is an integer of 1 or 2; or a salt thereof, have potent angiotensin II antagonistic activity and antihypertensive activity, thus being useful as therapeutic agents for treating circulatory system diseases such as hypertensive diseases, heart diseases (e.g. hypercardia, heart failure, cardiac infarction, etc.), strokes, cerebral apoplexy, nephritis, etc.

REFERENCES:
patent: 4880804 (1989-11-01), Carini et al.
patent: 5338756 (1994-08-01), Fortin et al.

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