Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1997-07-01
2000-03-07
Bernhardt, Emily
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
540557, A61K 3155, C07D49504
Patent
active
060340789
ABSTRACT:
Pharmaceutical compounds of the formula ##STR1## in which R.sup.1 is hydrogen or halo, and R.sup.2 is C.sub.1-10 alkyl, C.sub.2-10 alkenyl, C.sub.2-10 alkynyl, C.sub.3-6 cycloalkyl optionally substituted by 1 to 3 C.sub.1-4 alkyl groups, C.sub.3-6 cycloalkyl-C.sub.1-4 alkyl in which the cycloalkyl group is optionally substituted by 1 to 3 C.sub.1-4 alkyl groups, or optionally substituted phenyl-C.sub.1-4 alkyl; or a salt thereof. Such compounds are useful for treating a disorder of the central nervous system which is associated with the modulation of a 5-HT.sub.3 receptor.
REFERENCES:
patent: 3951981 (1976-04-01), Safir
patent: 4115568 (1978-09-01), Chakrabarti et al.
patent: 4725615 (1988-02-01), Coates et al.
patent: 5051516 (1991-09-01), Chakrabarti et al.
patent: 5114949 (1992-05-01), Gueremy et al.
patent: 5229382 (1993-07-01), Chakrabarti et al.
patent: 5561127 (1996-10-01), Tehim et al.
patent: 5602121 (1997-02-01), Fu
Medline Abstract for Ongini et al, Neuroscience Letters, 82(2) p206-210 (1987).
Saxena, Pharmac. Ther. 66, p 339-368 (1995).
Chakrabarti et al., J. Med. Chem., 23, 878-884 (1980).
Schmutz et al Chem. Abstracts, 80, No. 3562 (Jan. 7, 1984).
Barnes, J. M. Neuroscience Biobehavioural Review, 16:107-113.
Costall, B. Scand. J. Gastroenterology 25:769-787 (1990).
Dorland's Medical Dictionary 1045 (27th ed. 1988).
Fuller, R. W. Biology of Serotongergic Transmission, (John Wiley & Sons Ltd., 1982) p. 221-247.
Tupper, D. E., "The Pharmacology of Some Novel 10-Substituted Derivatives of Olanzapine", poster presented at Neuroscience Meeting, Washington, D.C., Nov. 7 through 12, 1993.
Waddinlton, Gen. Pharmacol. 19: 55-60 (1988).
Fairhurst John
Hotten Terrence Michael
Tupper David Edward
Wong David Taiwai
Bernhardt Emily
Eli Lilly and Company
Eli Lilly and Company Limited
Palmberg Arleen
Vorndran-Jones MacCharri
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