Thieno and furopyridinium-substituted cephalosporins

Details Thieno and furopyridinium-substituted cephalosporins Thieno and furopyridinium-substituted cephalosporins

1984-12-07

1986-03-18

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

544 25, 544 27, C07D50138, A61K 31545

Patent

active

045770140

ABSTRACT:
Cephalosporin compounds substituted in the 7-position by a 2-(5- or 6-membered heterocyclic)-2-oximinoacetylamino group and in the 3-position with a thienopyridinium methyl group or a furopyridinium methyl group are broad spectrum antibiotics highly effective in combating bacterial infections of gram-negative and gram-positive microorganisms. The cephalosporins are best prepared by reacting a silylated 7-[2-(heterocyclic)-2-oximinoacetylamino]-3-iodomethyl-3-cephem-4-carboxyl ic acid with the thienopyridine or the furopyridine. Pharmaceutical formulations comprising a compound of the invention and a method for treating bacterial infections comprising their use are also provided.

REFERENCES:
patent: 4258041 (1981-03-01), O'Callaghan et al.
patent: 4267176 (1981-05-01), Kamiyu et al.
patent: 4278671 (1981-07-01), Ochiai et al.
patent: 4278793 (1981-07-01), Durckheimer
patent: 4406898 (1983-09-01), Lunn et al.
patent: 4430499 (1984-02-01), Wheeler
patent: 4501739 (1985-02-01), Lunn et al.

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