Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1982-12-15
1985-02-26
Rizzo, Nicholas S.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
544 25, 544 27, 544 22, C07D50138, A61K 31545
Patent
active
045017395
ABSTRACT:
Cephalosporin compounds substituted in the 7-position by a 2-(5- or 6-membered heterocyclic)-2-oximinoacetylamino group and in the 3-position with a thienopyridinium methyl group or a furopyridinium methyl group are broad spectrum antibiotics highly effective in combating bacterial infections of gram-negative and gram-positive microorganisms. The cephalosporins are best prepared by reacting a silylated 7-[2-(heterocyclic)-2-oximinoacetylamino-3-iodomethyl-3-cephem-4-carboxyli c acid with the thienopyridine or the furopyridine. Pharmaceutical formulations comprising a compound of the invention and a method for treating bacterial infections comprising their use are also provided.
REFERENCES:
patent: 4258041 (1981-03-01), O'Callaghan et al.
patent: 4267176 (1981-05-01), Kamiya et al.
patent: 4278671 (1981-07-01), Ochiai et al.
patent: 4278793 (1981-07-01), Durckheimer
patent: 4406898 (1983-09-01), Lunn et al.
patent: 4430499 (1984-02-01), Wheeler
Lunn William H. W.
Vasileff Robert T.
Eli Lilly and Company
Rizzo Nicholas S.
Scanlon William B.
Whale Arthur R.
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