Thieno[3,4-d]pyrimidines

Details Thieno[3,4-d]pyrimidines Thieno[3,4-d]pyrimidines

1974-01-17

1976-01-06

Schenkman, Leonard

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260251A, 260251R, 2602471L, 424248, 424251, C07D23900

Patent

active

039312046

ABSTRACT:
Thieno[3,4-d]pyrimidines of the general formula: ##SPC1##
Wherein R.sub.1 is hydrogen, halogen, alkyl, alkoxy, amino, alkylamino, allylamino, hydroxy-alkylamino, cycloalkylamino, phenylamino, dialkylamino, di(hydroxyalkyl)-amino, alkyl-hydroxyalkyl-amino, pyrrolidino, piperidino, alkylpyrrolidino, alkylpiperidino, morpholino, alkyl-2-morpholino, alkyl-3-morpholino, dialkyl-3,5-morpholino, N-methylpiperazino, all said alkyl having 1 to 7 carbon atoms, said alkoxy having 1 to 5 carbon atoms and said cycloalkyl having 3 to 6 carbon atoms, R.sub.2 has the same meanings as R.sub.1 except alkyl and with the proviso that R.sub.2 is other than hydrogen or halogen, when R.sub.1 represents hydrogen or halogen and R.sub.3 is hydrogen or alkyl having 1 to 7 carbon atoms, as well as the addition salts thereof with pharmaceutically acceptable acids are, in particular, active on the cardiovascular system. Processes for their preparation are given.

REFERENCES:
patent: 3272811 (1966-09-01), Ohnacker et al.
patent: 3850919 (1974-11-01), Croisier
Chemical Abstracts Robba et al. 69:27365j (1968).

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