Thieno [3,2-c] pyridine derivatives and their therapeutic applic

Details Thieno [3,2-c] pyridine derivatives and their therapeutic applic Thieno [3,2-c] pyridine derivatives and their therapeutic applic

1983-07-05

1985-07-16

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514301, 544127, 544362, 546114, A61K 31435, C07D49504

Patent

active

045295964

ABSTRACT:
This invention relates to new thieno [3,2-c] pyridine derivatives having the formula: ##STR1## in which: Y represents the OH group or an OR group in which R is a straight or branched lower alkyl radical, or Y represents a group ##STR2## in which R.sub.1 and R.sub.2 are each independently of each other, hydrogen or a straight or branched lower alkyl group; or R.sub.1 and R.sub.2 form together and with the nitrogen atom to which they are attached a heterocycle which may include a second heteroatom such as oxygen or nitrogen, wherein the latter may be substituted by a lower alkyl or benzyl radical which may be substituted; and X represents hydrogen, a halogen or a lower alkyl radical; and their addition salts with pharmaceutically acceptable mineral or organic acids if Y represents the group OR or ##STR3## or with mineral bases if Y represents OH, as well as the two enantiomers or their mixture.
The invention also relates to the preparation process of new thieno [3,2-c] pyridine derivatives and to their therapeutic application as blood-platelet aggregation inhibiting agents and antithrombotics.

REFERENCES:
patent: 2527574 (1950-10-01), Rieveschl, Jr.

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