Thieno[2,3-B] pyridines as potassium channel inhibitors

Details Thieno[2,3-B] pyridines as potassium channel inhibitors Thieno[2,3-B] pyridines as potassium channel inhibitors

2005-12-09

2009-08-18

Seaman, D. Margaret (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

07576212

ABSTRACT:
The invention provides compounds of the formula:whereinR1 is aryl, heteroaryl, cycloalkyl or alkyl;R2 is H, alkyl, nitro, CO2R7, CONR5R6 or halo;R3 and R4 are H, NR5R6, NC(O)R7, halo, trifluromethyl, alkyl, CONR5R6, CO2R7, nitrile or alkoxy;R5 and R6 may be the same or different and may be H, alkyl, aryl, heteroaryl or cycloalkyl; or R5 and R6 may together form a saturated, unsaturated or partially saturated 4 to 7 member ring, wherein said ring may optionally comprise one or more further heteroatoms selected from N, O or S;R7 is H or alkyl;A is H, halo, or a group of formula X-L-Y;X is O, S or NR8;R8 is H or alkyl;L is (CH2)n, where n is 0, 1, 2, 3 or 4; andY is aryl, a heterocyclic group, alkyl, alkenyl or cycloalkyl;the products of mono- and di-oxidation of sulphur and/or mono-oxidation of nitrogen moieties in compounds of formula I;or a pharmaceutically acceptable salt thereof.These compounds find use as inhibitors of potassium ion channels and thus are useful in the treatment of various conditions including arrhythmia and type-2 diabetes mellitus.

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