Thiazolotriazine derivatives

Details Thiazolotriazine derivatives Thiazolotriazine derivatives

1982-04-01

1984-05-08

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

C07D51304

Patent

active

044476043

ABSTRACT:
Thiazolotriazine derivatives having the formula I ##STR1## their pharmaceutically acceptable salts, pharmaceutically acceptable triazolotriazinium compounds containing the cation having formula II ##STR2## and their zwitterionic forms and pharmaceutically acceptable acid addition salts [where A is hydroxy whilst B is hydrogen or A and B together represent a direct bond; R.sup.1 is aryl; R.sup.2 and R.sup.3 are independently lower alkyl or ar(lower)alkyl] are novel compounds useful as anti-cancer agents.

REFERENCES:
patent: 4127660 (1978-11-01), Boyle
Pratt and Ruddon, "The Anticancer Drugs", Oxford Univ. Press, New York (1979), pp. 273-276.
Carter et al. (Eds), "Principles of Cancer Treatment", McGraw-Hill Book Co., (1982), pp. 95, 107-114 & 121.

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