Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1994-04-01
1997-02-04
Bernhardt, Emily
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
5142332, 514258, 514221, 514368, 544117, 544278, 560 21, 560 43, 560 48, 560126, 560174, 560178, 564440, 540473, 540568, A61K 3155, A61K 31505, C07D51304
Patent
active
055998135
ABSTRACT:
Thiazolopyrimidine derivatives represented by the formula ##STR1## and salts thereof are provided, which are characterized by a carboxamide residue substituted with R.sup.4 and R.sup.5. The derivatives and salts thereof exhibit antiangiogenic activity and are useful for treatment and cure of diseases, the development of which may be related to angiogenesis, including diabetic retinopathy, various chronic inflammation conditions, growth or metastasis of malignant solid tumors, rheumatism and psoriasis.
REFERENCES:
Taylor et al, Nature 297 pp. 307-312 (1982).
Folkman et al, Science 221, pp. 719-725 (1983).
Chatani Haruko
Iwahana Michio
Matsumoto Hiroo
Nakayama Kiyoshi
Tanaka Noriko
Bernhardt Emily
Daiichi Pharmaceutical Co. Ltd.
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