Thiazolo(5,4-f)quinoline-8-carboxylic acid derivatives

Details Thiazolo(5,4-f)quinoline-8-carboxylic acid derivatives Thiazolo(5,4-f)quinoline-8-carboxylic acid derivatives

1976-02-25

1977-10-18

Rollins, Alton D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D51304

Patent

active

040545687

ABSTRACT:
Thiazolo[5,4-f]quinoline-8-carboxylic acid derivatives having either the general formula (I): ##STR1## wherein R.sub.1 is a lower alkyl group, a lower alkenyl group or a benzyl group; or the general formula (III-a): ##STR2## WHEREIN R.sub.3 is a lower alkyl group and X is a halogen atom; and methods for the preparation thereof. The compounds of the general formula (I) are useful as antibacterial agents against gram-negative and gram-positive bacteria. The compounds of the general formula (III-a) are useful as antifungal agents against eumycetes and also as an intermediate in a peparation of the compounds of the general formula (I).

REFERENCES:
patent: 3397208 (1968-08-01), Berman et al.
patent: 3665005 (1972-05-01), Harris
patent: 3714170 (1973-01-01), Dohmori et al.
patent: 3761482 (1973-09-01), Nakagome et al.
patent: 3882125 (1975-05-01), Dohmori et al.
Nagano et al., Chemical Abstracts, vol. 78, p. 403, abstr. no. 159,459p, (1973).
Ibid., vol. 80, p. 358, abst. no. 59,929q.

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