Thiazolo[3,4-b]isoquinolines

Details Thiazolo[3,4-b]isoquinolines Thiazolo[3,4-b]isoquinolines

1980-12-02

1982-12-14

Schwartz, Richard A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

424250, 424251, 424258, 544323, 544328, 544331, 544405, 546 80, C07D51304

Patent

active

043639097

ABSTRACT:
Isoquinoline derivatives of the formula ##STR1## wherein the symbol A.sub.1 represents an isoquinol-8-yl, 3-methylisoquinol-8-yl, 3-hydroxymethylisoquinol-5-yl, 3-carboxymethylisoquinol-5-yl, quinol-5-yl, thienopyridyl, benzimidazolyl, thienyl or thiazolyl radical, a 4-(or 5-)carboxyalkylthiazol-2-yl radical in which the alkyl moiety is linear or branched and contains 1 to 4 carbon atoms, or a 1,3,4-thiadiazol-2-yl, pyrazolyl, imidazolyl, pyrimidinyl, pyridazinyl or pyrazinyl radical, monocyclic heterocyclic rings within the definition of A.sub.1 being optionally substituted by a linear or branched alkyl radical containing 1 to 4 carbon atoms, in the (S) or (R,S) form or mixtures thereof, and salts thereof possess useful pharmocological properties, in particular antiviral activity.

REFERENCES:
patent: 4064247 (1977-12-01), Farge et al.
patent: 4153698 (1979-05-01), Farge et al.
De Long, D., et al., J. Infectious Diseases, 141(1), 87 (1980).
Reed, S., et al., J. Infectious Diseases, 133 (Supp), A128 (1976).
Phillpotts, R., et al., The Lancet, 1342 (1981).

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