Thiazolidinedione derivatives, their production and use

Details Thiazolidinedione derivatives, their production and use Thiazolidinedione derivatives, their production and use

1985-10-03

1988-02-16

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514342, 546280, 548183, C07D41712, A61K 31425

Patent

active

047256109

ABSTRACT:
Thiazolidinedione derivatives of the general formula: ##STR1## [wherein R.sup.1 is hydrogen or a hydrocarbon residue or heterocyclic residue which may each be substituted; R.sup.2 is hydrogen or lower alkyl which may be substituted by hydroxyl group; X is an oxygen or sulfur atom; Z is a hydroxylated methylene or carbonyl; m is 0 or 1; n is an integer of 1 to 3; L and M represent independently a hydrogen atom or L and M combine with each other to cooperate jointly to form a linkage] and their salts, which are novel compounds, possess blood-glucose and blood-lipid lowering actions in mammals, and are of value as a therapeutic agent for diabetes and therapeutic agent for hyperlipemia.

REFERENCES:
patent: 4287200 (1981-09-01), Kawamatsu et al.
patent: 4572912 (1986-02-01), Yoshioka et al.
Sohda et al., Chem. Pharm. Bull., vol. 32(6), pp. 2267-2278, (1984).
Shoda et al., Chem. Pharm. Bull., 30(10), 3580-3600, (1982).
Shoda et al., Chem. Pharm. Bull., 30(10), 3563-3573, (1982).
Fujita et al., Diabetes, vol. 32, 804-810, (1983).

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