Thiazolidine compounds and pharmaceutical compositions...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S342000, C514S369000, C546S167000, C546S270400, C548S183000

Reexamination Certificate

active

07026334

ABSTRACT:
Pharmaceutical compositions containing as an active ingredient compounds of the general formula (I), prodrugs of the same, pharmaceutically acceptable salts of both, or solvates of them and exhibiting thrombopoietin receptor agonism:wherein X1is optionally substituted heteroaryl or the like; Y1is —NRACO— (CH2)0-2— or the like (wherein RAis a hydrogen or the like); Z1is optionally substituted arylene or the like; and A1is a ring represented by general formula (II) or (III):

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B. Hulin et al., “Novel Thiazolidine-2,4-diones as Potent Euglycemic Agents,” J. Med. Chem., 25, 1992, pp. 1853-1864.
M. Ebisawa et al., “Novel Thiazolidinedione Derivatives with Retinoid Synergistic Activity,” Biol. Pharm. Bull 21(5), May 1998, pp. 547-549.
H. Sugimoto et al., “Metabolic Changes of Prostaglandis in Diabetic Rats and Restoration by Insulin Therapy,” Fukuoka Acta Med. 73(2), 1982, pp. 76-83.

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