Thiazole pyrazolopyrimidines CRF1 receptor antagonists

Details Thiazole pyrazolopyrimidines CRF1 receptor antagonists Thiazole pyrazolopyrimidines CRF1 receptor antagonists

2007-09-17

2011-10-04

Chong, Yong (Department: 1627)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S256000, C514S257000, C514S267000, C514S359000, C514S365000, C514S366000, C514S403000

Reexamination Certificate

active

08030304

ABSTRACT:
The present invention relates to compounds of Formula (I), pharmaceutical compositions thereof, and use thereof as corticotropin releasing factor 1 (CRF1) receptor antagonists in the treatment of psychiatric and neuroendocrine disorders, neurological diseases, and metabolic syndrome.

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Chen, et al., Design of 2,5-Dimethyl-3-(6-dimethyl-4-methylpyridin-3-yl)-7-dipropyl aminopryazolo[1,5-a]pyrimidine (NBI 30775/R121919) and Structure-Activity Relationships of a Series of Potent and Orally Active Corticotropin- Releasing Factor Receptor Antagonists', J. O Medicinal Chemistry Society. Washington, US .47(19) 4787-4798, XP001206057 (2004).
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