Thiazole derivatives useful in therapy as anti-depressant agents

Details Thiazole derivatives useful in therapy as anti-depressant agents Thiazole derivatives useful in therapy as anti-depressant agents

1980-02-04

1981-08-04

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

548154, 548155, 424270, 544278, C07D27760, C07D23900, C07D27700, A61K 31425, A61K 31505

Patent

active

042822254

ABSTRACT:
Thiazole derivatives of general formula (I) ##STR1## in which n is 1 or 2 and Ar represents a phenyl radical unsubstituted or substituted by one or more substituents selected from halogen atoms, the radical CF.sub.3, the phenyl radical straight or branched chain alkyl radicals having 1 to 4 carbon atoms, and cycloalkyl radicals having 3 to 6 carbon atoms, and their pharmaceutically acceptable acid addition salts are useful in therapy as anti-depressive agents. They are prepared by reacting the thiazole ##STR2## with a ketone X--CH.sub.2 --CO--CH.sub.2 O--Ar (III) (X is a leaving group, such as halogen).

REFERENCES:
patent: 2853872 (1974-12-01), Wei et al.
patent: 3671533 (1972-06-01), Houlihan et al.
patent: 4059588 (1977-11-01), Baklien et al.

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