Thiazole derivatives

Details Thiazole derivatives Thiazole derivatives

1973-08-16

1976-01-13

Gallagher, Richard J.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260243B, 260250BN, 2602565R, 260287F, 260287CE, 260288CE, 26029368, 2602948D, 260302H, 260302S, 26029357, 424246, 424248, 424250, 424251, 424258, 424263, 424267, 424270, C07D27736

Patent

active

039324001

ABSTRACT:
This invention relates to thiazole derivatives of the formula (I): ##EQU1## wherein R.sub.1 and R.sub.2 are each hydrogen, lower alkyl, cycloalkyl, optionally substituted aryl or optionally substituted heteroaromatic rings containing oxygen, sulfur, nitrogen or combinations thereof, and R.sub.3 and R.sub.4 are each hydrogen or lower alkyl and salts thereof. The thiazole derivatives of the formula (I) have excellent pharmacological properties such as .beta.-adrenergic receptor blocking effects and are valuable compounds exerting preventive or therapeutic effects on heart diseases, for example, arrhythmia, coronary heart disease, etc.

REFERENCES:
patent: 2221147 (1940-11-01), Mathes
patent: 3158623 (1964-11-01), Von Esch et al.
patent: 3228952 (1966-01-01), Reifschneider
Wagner et al., Synthetic Organic Chemistry, N.Y., John Wiley & Sons, 1953, pp. 787-788.

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