Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-04-21
1993-11-02
Morris, Patricia L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548194, A61K 31425, C07D27742
Patent
active
052583961
ABSTRACT:
A novel thiazole derivative represented by the following general formula [1] and a pharmaceutically acceptable salt thereof: ##STR1## wherein A is a single bond, a straight-chained or branched lower alkylene group or a straight-chained or branched lower alkenylene group; B is a single bond or --CO--; R.sup.1 is a carboxy group or --CON(R.sup.7)OR.sup.8 (R.sup.7 and R.sup.8 are independently of each other a hydrogen atom or a lower alkyl group); R.sup.2 is a lower alkyl group; R.sup.3 and R.sup.4 are independently of each other a hydrogen atom, a lower alkyl group or a lower alkoxycarbonyl group; R.sup.5 is a hydrogen atom or a halogen atom; and R.sup.6 is a hydrogen atom, a halogen atom, a lower alkyl group, a hydroxy group, a lower alkoxy group, a thiol group, a lower alkylthio group, a lower alkylsulfinyl group, a lower alkylsulfonyl group, a nitro group, an amino group, a substituted amino group, a cyano group, a carboxy group or an acyl group.
The compounds of the present invention are useful as therapeutic or preventive drugs for autoimmune diseases and inflammatory diseases.
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J. Chem. Soc., Perkins Trans. I, (1983), pp. 1677-1680, Kaye et al.: "N,N-Disubstituted 2-Aminothizole-5-carboxylates: Preparation and Rotation of Functional Groups".
Chemical Abstracts, vol. 86, No. 13, Mar. 28, 1977, Columbus, Ohio, U.S.; abstract No. 89798N, p. 543.
Kimura Yoshihiko
Masumori Hiroaki
Saji Ikutaro
Tanno Norihiko
Morris Patricia L.
Sumitomo Pharmaceuticals Company Limited
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