Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...
Patent
1974-09-19
1976-09-21
Schenkman, Leonard
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Parasitic organism or component thereof or substance...
424248, 424267, A61K 31425
Patent
active
039820106
ABSTRACT:
1-Amino-3-[2-thiazoloxy]-2-propanol and substituted 1-amino derivatives thereof; 3-[2-thiazoloxy]-1,2-epoxypropane 5-[thiazol-2-oxymethylene]-oxazolidine and/or N-substituted and/or 2-substituted oxazolidine, derivatives thereof and methods of preparing such compounds. The above 1-amino-3-[2-thiazoloxy]-2-propanol and derivatives exhibit .beta.-adrenergic stimulating cardiovascular activity and are useful for the treatment of abnormal heart conditions in mammals. The above 3-[2-thiazoloxy]-1,2-epoxypropane and derivatives are useful as intermediates for the aforementioned cardiovascular agents. The 5-[thiazol-2-oxymethylene]-oxazolidine and derivatives are intermediates for aforementioned cardiovascular agents. The 1-amino-3-[2-thiazoloxy]-2-propanol and derivatives can be prepared by base or acid hydrolysis of the corresponding 5-[thiazol-2-oxymethylene]-oxazolidine or derivatives; or by treatment of the corresponding 3-[2-thiazoloxy]-2,3-epoxypropane or derivative with the desired amine or amino-derivative.
REFERENCES:
patent: 3328417 (1967-06-01), McLoughlin et al.
patent: 3631055 (1971-12-01), Posselt et al.
patent: 3729469 (1973-04-01), Wasson
patent: 3850945 (1974-11-01), Edwards
Schenkman Leonard
Squires Lawrence S.
Syntex (U.S.A.) Inc.
Walker William B.
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