Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-01-15
2000-01-04
Fan, Jane
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
5462697, 546256, 514333, C07D41710, A61K 3144
Patent
active
060110481
ABSTRACT:
Thiazole substituted benzenesulfonamides are .beta..sub.3 adrenergic receptor agonists with very little .beta..sub.1 and .beta..sub.2 adrenergic receptor activity and as such the compounds are capable of increasing lipolysis and energy expenditure in cells. The compounds thus have potent activity in the treatment of Type II diabetes and obesity. The compounds can also be used to lower triglyceride levels and cholesterol levels or raise high density lipoprotein levels or to decrease gut motility. In addition, the compounds can be used to reduced neurogenic inflammation or as antidepressant agents. The compounds are prepared by coupling an aminoalkylphenyl-sulfonamide with an appropriately substituted epoxide. Compositions and methods for the use of the compounds in the treatment of diabetes and obesity and for lowering triglyceride levels and cholesterol levels or raising high density lipoprotein levels or for decreasing gut motility are also disclosed.
REFERENCES:
patent: 5451677 (1995-09-01), Fisher et al.
patent: 5561142 (1996-10-01), Fisher et al.
patent: 5705515 (1998-01-01), Fisher et al.
Mathvink Robert J.
Parmee Emma R.
Tolman Samuel
Weber Ann E.
Fan Jane
Merck & Co. , Inc.
Rose David L.
Yang Mollie M.
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