Thiazole and oxazole VDAC regulator

Details Thiazole and oxazole VDAC regulator Thiazole and oxazole VDAC regulator

2003-03-13

2008-12-09

McKane, Joseph (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S365000, C514S397000

Reexamination Certificate

active

07462635

ABSTRACT:
The present invention provides a VDAC regulator comprising a compound represented by the formula (I):wherein R1is a halogen atom, an optionally substituted heterocyclic group, an optionally substituted hydroxyl group, an optionally substituted thiol group or an optionally substituted amino group; A is an optionally substituted acyl group, an optionally substituted heterocyclic group, an optionally substituted hydroxyl group or an optionally esterified or amidated carboxyl group; B is an optionally substituted aromatic group; X is an oxygen atom, a sulfur atom or an optionally substituted nitrogen atom; and Y is a divalent hydrocarbon group or heterocyclic group; a salt thereof or a prodrug thereof, which is useful as an agent for the prophylaxis or treatment of Down's syndrome and the like.

REFERENCES:
patent: 5464847 (1995-11-01), Courtemanche et al.
patent: 6605629 (2003-08-01), Momose et al.
patent: 2002/0010195 (2002-01-01), Ghosh et al.
patent: 0 560 136 (1993-09-01), None
patent: 2000-287689 (2000-10-01), None
Thompson et al., Science vol. 267, Mar. 10, 1995, pp. 1456-1462.
Shimizu et al., “Essential Role of Voltage-Dependent Anion Channel in Various Forms of Apoptosis in Mammalian Cells,” The Journal of Cell Biology, vol. 152, No. 2, Jan. 22, 2001, pp. 237-250.
Sampson et al., “The Murine Voltage-dependent Anion Channel Gene Family”, The Journal of Biological Chemistry, Vo. 272, No. 30, pp. 18966-18973.
Thompson, “Apoptosis in the Pathogenesis and Treatment of Disease”, Science vol. 267, Mar. 10, 1995, pp. 1456-1462.
Yoo et al., “Changes of voltage-dependent anion-selective channel proteins VDAC1 and VDAC2 brain levels in patients with Alzheimer's disease and Down Syndrome”, Electrophoresis 2001, 22, pp. 172-179.
Shimizu et al., “Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC”, Nature, vol. 399, Jun. 3, 1999, pp. 483-487.
Kogaku, Players That Regulate Apoptosis, VDAC, Functional Target of Gcl-2 Family, Cell Technology, Vo. 18, No. 12, 1999, pp. 1765-1772 (English Translation Attached—14 pages).
Wong et al. “The Friedreich's ataxia mutation confers cellular sensitivity to oxidant stress which is rescued by chelators of iron and calcium and inhibitors of apoptosis”, Human Molecular Genetics, 1999, Vo. 8, No. 3 pp. 425-430.

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