Thiazine derivatives and preparation thereof

Details Thiazine derivatives and preparation thereof Thiazine derivatives and preparation thereof

1992-09-23

1994-01-25

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142305, 544 52, 544105, A61K 3154, C07D27916

Patent

active

052815927

ABSTRACT:
Thiazine derivatives of the formula [I]: ##STR1## wherein R.sup.1 and R.sup.2 are both H or form a naphthalene ring together with the benzene ring; R.sup.3 and R.sup.4 are both H, or one of them is halogen and another is H; X is S or O; R.sup.5 and R.sup.6 are each i) H, ii) lower alkyl, iii) cycloalkyl, iv) substituted phenyl, v) naphthyl, vi) lower alkyl which is substituted by substituted or unsubstituted phenyl, or vii) S-containing heterocyclic group; one of Z.sup.1 and Z.sup.2 is O and another is H.sub.2 ; A is lower alkylene; R.sup.7 and R.sup.8 are each i) H, ii) lower alkyl, iii) lower alkenyl, iv) lower alkynyl, or v) lower alkyl which is substituted by substituted or unsubstituted phenyl, or both form together N-containing heterocyclic group; provided that when both of R.sup.1 and R.sup.2 are H, Z.sup.2 is O and either one of R.sup.5 and R.sup.6 is substituted phenyl, naphthyl or S-containing heterocyclic group, or their salts, which have calcium antagonistic activity within the cerebral tissues and are useful for prophylaxis and treatment of ischemic encephalopathia and/or cerebral neurocyte dyscrasia, and process for preparing said compounds.

REFERENCES:
patent: 3143545 (1964-08-01), Lowrie et al.
patent: 3395150 (1968-07-01), Krapcho
patent: 3547915 (1970-12-01), Oskar Bub et al.
patent: 3547915 (1970-12-01), Bub
patent: 3681330 (1972-08-01), Pesson
patent: 3705894 (1972-12-01), Gerzon et al.
patent: 3748321 (1973-07-01), Krapcho
patent: 3879522 (1975-04-01), Pesson
patent: 4107167 (1978-08-01), Lorenz et al.
patent: 4534300 (1986-04-01), Iwao et al.
Iwao et al.; "Chemical Abstract" vol. 104(13), (1985) #109666P.
Iwao et al., "Chemical Abstract" vol. 102(3) (1984) #24637P.
George Roger Clemo et al., Journal of the Chemical Society Transactions, vol. 121, pp. 642-649 (1922).
Abstract of Japan 60-166674 (A), vol. 10, No. 13(C-323) (2070), Jan. 1986.

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