Thianaphthene derivatives

Details Thianaphthene derivatives Thianaphthene derivatives

1987-01-27

1989-07-11

Fan, Jane T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514397, 546274, 548336, C07D40906, A61K 31415

Patent

active

048472727

ABSTRACT:
Compounds of formula (I): ##STR1## (wherein n is 0 or 1, R.sup.1 and R.sup.2 are hydrogen or alkyl, one of A.sup.1 and A.sup.2 is --Z--Y and the other is --W--COOH, where W and Z are alkenylene or alkylene and Y is imidazolyl or pyridyl, and the broken lines represent two single bonds or one single bond and one double bond) and their salts, esters and amides have the ability to inhibit the synthesis of thromboxane A.sub.2 and hence are useful in the treatment or prophylaxis of thrombotic conditions. They may be prepared by introducing an imidazolyl or pyridyl group into the corresponding compound in which Y is replaced by an active group or atom.

REFERENCES:
patent: 4410539 (1983-10-01), Cross et al.
patent: 4496572 (1985-01-01), Cross et al.
patent: 4611059 (1986-09-01), Sih

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