Thiaminases and thiaminase genes for use in apoptotic therapies

Details Thiaminases and thiaminase genes for use in apoptotic therapies Thiaminases and thiaminase genes for use in apoptotic therapies

2000-09-29

2010-06-15

Ton, Thaian N (Department: 1632)

Chemistry: molecular biology and microbiology

Process of mutation, cell fusion, or genetic modification

Introduction of a polynucleotide molecule into or...

C435S325000, C435S455000, C435S320100, C424S093210, C424S093400, C536S023100

Reexamination Certificate

active

07736898

ABSTRACT:
This disclosure describes methods for preparing and utilizing thiaminase and thiaminase genes to induce apoptosis in a selected group of vertebrate cells in vivo by reducing the level of thiamin in the cells. Emphasis is on methods for inducing apoptosis in cancer cells.

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